Personally I don’t think I’d use it on my main phone as of now. While it does work well and the granular options for sandboxing/security are awesome, I’d worry about compatibility with banking apps and other more locked down software that, from what I’ve heard, will refuse to run under GrapheneOS. Also, yeah you’d be missing out on some of the exclusive Pixel features that are part of Google’s stock ROM. But overall it works well and handles Play Store backend stuff pretty seamlessly while still keeping the security tight.
From what I understand camera quality and other features may be less performant than stock as well, though in the case of my Pixel 5a the camera experience wasn’t that great before anyways so it didn’t matter to me.
For now on my main phone I’m just gonna keep using stock and dipping into Android betas to mess with the new stuff coming to Pixel phones. Maybe once my desire to be part of that ecosystem is lessened I’d just go for Graphene on my Pixel 7.
I pretty much just use my switch for Nintendo exclusives at this point. For the games I do own on both I tend to prefer the Deck’s input options and flexibility in that regard more often than not.