Short answer: Yes. ID75 or XD75 pack in a full set of keys in 80% case. Some are pretty ridiculous - BFO-9000 or FU!Keyboard
Long answer: most orthos are designed so that you can hold layer shift keys with your thumbs(RSE, LWR for Raise and Lower) to type other keys(e.g. Lower+J types “-“ and Raise+J types “_”). This way you type the keys of a full layout without moving your hands off home row and with less keys overall.
Are there full-size ortho keyboards?
Short answer: Yes. ID75 or XD75 pack in a full set of keys in 80% case. Some are pretty ridiculous - BFO-9000 or FU!Keyboard
Long answer: most orthos are designed so that you can hold layer shift keys with your thumbs(RSE, LWR for Raise and Lower) to type other keys(e.g. Lower+J types “-“ and Raise+J types “_”). This way you type the keys of a full layout without moving your hands off home row and with less keys overall.